Hyaluronic Acid

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Percent of consumer reviews saying "Yes":

87% Breast implants
86% Tummy tuck
85% Pixel laser
83% Invisalign
82% Blepharoplasty
82% Silicone breast implants
81% Smart Lipo
80% Saline breast implants
79% Facelift
79% VASER Liposelection
76% Laser hair removal
75% Laser resurfacing
75% Lasik
74% Botox
73% Permanent makeup
71% Rhinoplasty
70% Deep FX
70% Fraxel Repair
68% Active FX
66% Chemical peel
64% Juvederm
63% Microdermabrasion
61% Restylane
61% Perlane
58% Sculptra
56% Liposuction
54% IPL
53% Radiesse
52% Fraxel Laser
50% Accent XL
49% Mesotherapy
42% Zoom teeth whitening
41% Lifestyle lift
40% TITAN
37% Thermage
37% Lipodissolve
33% Brite Smile
18% Velasmooth
18% Velashape
14% Thread lift

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Hyaluric Acid, Sodium Hyaluronate and Potassium Hyaluronate are white fiber-like or creamy powders. In cosmetics and personal care products, these ingredients are used mainly in the formulation of skin care products, lipsticks and eye and facial makeup.

The safety of Hyaluronic Acid, Sodium Hyaluronate and Potassium Hyaluronate has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that Hyaluronic Acid, Sodium Hyaluronate and Potassium Hyaluronate were safe as cosmetic ingredients.CIR Safety Review: The CIR Expert Panel noted that Hyaluronic Acid penetrated to the dermis and can moderate the penetration of other chemicals. The amount of Hyaluronic Acid normally found in the skin was compared to the maximum amount of Hyaluronic Acid applied to the skin by cosmetics and personal care products (2% of product). The CIR Expert Panel found that the contribution of Hyaluronic Acid to the skin via application of such a product to be negligible.

The CIR Expert Panel reviewed acute, short-term and chronic toxicological studies and concluded that they did not demonstrate any cause for concern. Hyaluronic Acid did not cause reproductive or developmental toxicity. There was no genotoxicity found in reverse mutation tests, micronucleus tests and chromosomal aberration tests.

There were no skin reactions in an immunogenicity test of Sodium Hyaluronate on humans. Hyaluronic Acid also has medical uses in which it is injected into the body. In 2000, there were 144 reported adverse reactions from medical injection use of Hyaluronic Acid out of a possible 262,000 uses. Most reactions were resolved within 2 weeks. In the case reports of adverse effects from Hyaluronic Acid that have appeared, most were related to its use as a treatment for osteoarthritis or for tissue augmentation, and all these cases were from injections and not topical use. Moreover, there were no reported reactions to topically applied Hyaluronic Acid, further supporting that Hyaluronic Acid at levels currently used in cosmetics and personal care products applied to the skin should not be of concern.

Hyaluronic Acid, Sodium Hyaluronate and Potassium Hyaluronate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union. Ingredients of animal origin must comply with European Union animal by-products regulations.
Link to the EU Cosmetics Directive: http://ec.europa.eu/enterprise/cosmetics/html/consolidated_d...

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